Treatment of Myasthenia Gravis Exacerbation With Intravenous Immunoglobulin

Treatment of myasthenia gravis exacerbation with intravenous immunoglobulin: a randomized double-blind clinical trial.

BACKGROUND The optimal dose of intravenous immunoglobulin (IVIG) in acute exacerbation of myasthenia gravis remains unknown. Increasing the treatment duration might provide added efficacy. OBJECTIVE To determine the optimal dose of IVIG for treating myasthenia gravis exacerbation. DESIGN Randomized double-blind placebo-controlled multicenter trial designed to demonstrate superiority of the ...

High-dose intravenous immunoglobulin for myasthenia gravis.

An 7-year-old girl with ocular myasthenia gravis (MG) refractory to prednisolone and anticholinesterase compounds was treated with high-dose intravenous immunoglobulin (IVIg). Ocular symptoms disappeared rapidly by the administration of IVIg 300 mg/kg/day for five consecutive days. Booster infusions of IVIg at an interval of 2 weeks appeared to be effective in maintaining a remission at least a...

Immunoglobulin treatment in refractory Myasthenia gravis.

Failure to induce and maintain remission in severe exacerbations of myasthenia gravis (MG), despite optimal care, is a common problem. We evaluated the efficacy and safety of high-dose intravenous immunoglobulin (IVIg) therapy in an open-label study of 10 patients with severe generalized myasthenia and an acute deterioration unresponsive to conventional therapy including high-dose corticosteroi...

Long-term treatment of refractory myasthenia gravis with subcutaneous immunoglobulin

Introduction Myasthenia gravis (MG) is an autoimmune disease characterized by fatigue and weakness of skeletal muscles. Laryngeal myasthenia (when dysphonia is the initial and primary complaint) is a rare variant of MG (0.46%),1 which may provide a diagnostic challenge. Although with adequate treatment majority of myasthenic patients can live productive lives with no or few symptoms, there is a...

Statin-associated exacerbation of myasthenia gravis.